Optimal Tobramycin Dosage in Patients with Cystic Fibrosis - Evidence for Predictability Based on Previous Drug Monitoring

Comparing dosage adjustment methods for once-daily tobramycin in paediatric and adolescent patients with cystic fibrosis.

BACKGROUND AND OBJECTIVES Several dosage adjustment methods are currently available to individualize intravenous tobramycin dosing. This study compared different methods in terms of their recommendations for dosage adjustment, their estimation of patients' pharmacokinetic parameter values and their ability to predict subsequent observed tobramycin concentrations following once-daily tobramycin ...

Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.

BACKGROUND AND METHODS We conducted two multicenter, double-blind, placebo-controlled trials of intermittent administration of inhaled tobramycin in patients with cystic fibrosis and Pseudomonas aeruginosa infection. A total of 520 patients (mean age, 21 years) were randomly assigned to receive either 300 mg of inhaled tobramycin or placebo twice daily for four weeks, followed by four weeks wit...

A New Approach to Therapeutic Drug Monitoring of Tobramycin in Cystic Fibrosis

Monitoring of tobramycin levels in patients with cystic fibrosis by finger-prick sampling.

The present study did not examine whether an intervention, such as intravenous antibiotics, is able to reduce the increase in arterial stiffness; however, a recent study published in abstract form seems to reveal benefits of interventions aiming to reduce inflammation on the cardiovascular system in adult CF patients [10]. It remains unclear whether these interventions completely normalise the ...

Evidence of Inhaled Tobramycin in Non-Cystic Fibrosis Bronchiectasis

There is currently less experience with inhaled tobramycin in non-cystic fibrosis bronchiectasis than in cystic fibrosis (CF). Intravenous formulation and solution for inhalation (TSI) have been studied in non-CF bronchiectasis patients with chronic P. aeruginosa bronchial infection. An improvement in clinical parameters and a reduction in bacterial density have been shown with both inhaled sol...